alpha-Chloropropionic acid
2-Chloropropionic acid
CAS: 598-78-7
Molecular Formula: C3H5ClO2
alpha-Chloropropionic acid - Names and Identifiers
| Name | 2-Chloropropionic acid |
| Synonyms | α-Chloropropionic acid A-CHLOROPROPIONIC ACID 2-Chloropropionic acid 2-Chloropropionoic acid MONO-CHLOROPROPANOICACID Propanoic acid, 2-chloro- (n)-2-chloropropionic acid ALPHA-CHLOROPROPIONIC ACID alpha-Chloropropionic acid (2S)-2-chloropropanoic acid 2-CHLOROPROPIONIC ACID pract |
| CAS | 598-78-7 |
| EINECS | 209-952-3 |
| InChI | InChI=1/C3H5ClO2/c1-2(4)3(5)6/h2H,1H3,(H,5,6)/t2-/m0/s1 |
alpha-Chloropropionic acid - Physico-chemical Properties
| Molecular Formula | C3H5ClO2 |
| Molar Mass | 108.52 |
| Density | 1.182 g/mL at 25 °C(lit.) |
| Melting Point | -12--14 °C |
| Boling Point | 170-190°C(lit.) |
| Flash Point | 215°F |
| Water Solubility | freely soluble |
| Solubility | H2O: soluble |
| Vapor Presure | 4 mm Hg ( 20 °C) |
| Appearance | clear liquid |
| Color | Colorless to Almost colorless |
| Exposure Limit | ACGIH: TWA 0.1 ppm (Skin) |
| BRN | 1720259 |
| pKa | 2.96±0.10(Predicted) |
| PH | <1 (200g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. |
| Refractive Index | n20/D 1.4345(lit.) |
| Physical and Chemical Properties | Density: 1.182 melting point -12-14°C Boiling Point: 170-190°C refractive index: 436 flash point: 107°C water-soluble freeely soluble |
| Use | For pesticides, pharmaceuticals, dye intermediates and other organic synthesis |
alpha-Chloropropionic acid - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R22 - Harmful if swallowed R35 - Causes severe burns R21/22 - Harmful in contact with skin and if swallowed. |
| Safety Description | S23 - Do not breathe vapour. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S28A - |
| UN IDs | UN 2511 8/PG 3 |
| WGK Germany | 1 |
| RTECS | UE8575000 |
| TSCA | Yes |
| HS Code | 29159080 |
| Hazard Class | 8 |
| Packing Group | III |
alpha-Chloropropionic acid - Upstream Downstream Industry
| Raw Materials | Propionic acid Chlorine |
| Downstream Products | DL-Alanine Ibuprofen |
alpha-Chloropropionic acid - Reference Information
| LogP | 0.82 at 20.5℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| uses | α-chloropropionic acid is the fungicide metalaxyl, benzalene, oxaoling, herbicide grass spirit, intermediates of pyriflometrine, thiazole grass, oxazole grass, flupiriline, ruflumehraline, and thallus, 2,4 drops of propionate, 2me4chloropropionate, etc. It is mainly used in the production of pesticides and herbicides. 2-chloropropionic acid is also used in the production of lactic acid and lower alcohol esters of industrial value.. intermediates for pesticides, pharmaceuticals, dyes and other organic synthesis intermediates for organic synthesis and herbicides |
| production method | is derived from the chlorination of propionic acid. The preparation method is to add propionic acid and a certain amount of catalyst PCl3 in the reaction kettle, and inject chlorine at 120~125 ℃ to control the relative density of the reactants to reach the end of the reaction, stop chlorine gas, cool to room temperature, remove excess chlorine and hydrogen chloride with air or nitrogen, and obtain product by decompression and fractionation. CH3CH2COOH Cl2[PCl3]→CH3CHClCOOH HCl |
| category | corrosive article |
| toxicity grade | high toxicity |
| Acute toxicity | subcutaneous-guinea pig LD50: 126 mg/kg |
| flammability hazard characteristics | flammable; Thermal decomposition of toxic chloride fumes |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from oxidants and alkalis. |
| fire extinguishing agent | Sand, foam, water mist, carbon dioxide |
| Occupational Standard | TLV-TWA 0.1 PPM; Tel 2 mg/m3 |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:09
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Raw Materials for alpha-Chloropropionic acid
Downstream Products for alpha-Chloropropionic acid